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Our in vivo experiments confirmed that orally administered KPV significantly decreased inflammation in DSS- and TNBS-induced colitis. KPV lowered lack of body weight, colonic MPO activity, and markedly decreased histological signs of inflammation and pro-inflammatory cytokines mRNA levels.
This work constitutes the primary report of KPV-mediated reduction of colitis. Our in vitro experiments instructed that this anti-inflammatory function of KPV outcomes from inhibition of pro-inflammatory mechanisms in each IEC and immune cells. Human intestinal epithelial cells (Caco2-BBE and HT29-Cl.19A), and human T cells (Jurkat) were stimulated with pro-inflammatory cytokines in the presence or absence of KPV.


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